Brindisi railway station (Italian: Stazione di Brindisi) is the main station serving the city and comune of Brindisi, in the region of Apulia, southern Italy. Opened in 1865, it forms part of the Adriatic Railway (Ancona–Lecce), and is also a junction for, and terminus of, the Taranto–Brindisi railway.
The station is currently managed by Rete Ferroviaria Italiana (RFI). However, the commercial area of the passenger building is managed by Centostazioni. Train services are operated by behalf of Trenitalia. Each of these companies is a subsidiary of Ferrovie dello Stato (FS), Italy's state-owned rail company.