Hesperange (Luxembourgish: Hesper, German: Hesperingen) is a commune and town in southern Luxembourg. It is located south-east of Luxembourg City.
The total population of the commune is 13,103 persons. This breaks down into 6,442 Luxembourgers, 1,480 Portugueses, 1,318 French, 865 Italians, 443 Belgians, 427 Germans, and 2,128 persons of other nationalities.
As of 2008, the town of Hesperange, which lies in the centre of the commune, has a population of 2,376. Other towns within the commune include Alzingen, Fentange, Howald, and Itzig. Each of these five towns has a population of over 1,000, making Hesperange unique amongst Luxembourgian communes in having five towns with over a thousand inhabitants (see: List of towns in Luxembourg by population).
The mayor of the commune is Marc Lies.
Hesperange is home of FC Swift Hesperange, a football club that plays in the top-flight National Division. The club's home games are played at Stade Alphonse Theis. They have won the Luxembourg Cup on one occasion (1989–90).
Hesperange Castle, now a ruin, has a history dating from the 13th century.