Khon Kaen Wittayayon School (Thai: โรงเรียนขอนแก่นวิทยายน) is a public school located in downtown Khon Kaen Province, Thailand. It admits secondary students (mathayom 1–6, equivalent to grades 7–12). Founded in 1897 as a boy school for Khon Kaen Province, then first coeducational school in Khon Kaen. Her former name were "Khon Kaen (boy) School" and "That Wittayakhan Temple School". The first school principal was Mr. Tub Chimma.