San Callisto (English: Saint Callistus, Latin: S. Calixti) is a Roman Catholic titular church in Rome, Italy, built over the site of Saint Pope Callistus I and the location of his martyrdom. The original building dates form the time of Pope Gregory III who order the building of a church on the site. The church has been rebuilt twice since, first in the twelfth century and again the current church in 1610. In 1458 Pope Callixtus III granted it a titular church as a seat for Cardinals.
Established in 1517, the Titulus San Calixti has been vacant since 2003.