The Church of St. Pantaleon is an early Romanesque church in Cologne, Germany. The church dates back to the 10th Century and is the oldest of the twelve Romanesque churches of Cologne. The former monastery church is consecrated to Saint Pantaleon and the Saints Cosmas and Damian. The empress Theophanu and the archbishop Bruno the Great are buried in the church. Pope Benedict XVI visited the church in 2005.
The coffered ceiling in the nave, depicting the Tree of Jesse and portraits of various saints, was designed and realised by artist Dieter Hartmann and was made possible by support of the booster club for the Romanesque churches of Cologne. The ceiling in the flanking westwork was done by artist Gerhard Kadow in 1966, and depicts the Heavenly Jerusalem.